Synthesis of the B-seco limonoid core scaffold

• Hanna Bruss,
• Hannah Schuster,
• Rémi Martinez,
• Markus Kaiser,
• Andrey P. Antonchick and
• Herbert Waldmann

Beilstein J. Org. Chem. 2014, 10, 194–208, doi:10.3762/bjoc.10.15

• the developed strategy ended up failing in more complex and sterically demanding systems. Keywords: B-seco limonoids; biology oriented synthesis; Ireland–Claisen rearrangement; natural products; tetranortriterpenoids; Introduction B-seco limonoids are a family of more than 100 highly oxygenated

• a trans-fused bicyclic C–D ring having an exo-methylene moiety. The crowded C9–C10 bond bridging the two domains is the main synthetic obstacle. Taking into account the biology-oriented synthesis (BIOS) concept [27][28][29][30][31][32][33][34], which employs the scaffolds of biologically relevant

Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks

• Sushil K. Maurya,
• Mark Dow,
• Stuart Warriner and
• Adam Nelson

Beilstein J. Org. Chem. 2013, 9, 775–785, doi:10.3762/bjoc.9.88

• particular, play a key role in guiding the navigation of chemical space [2][3][4]. The field of biology-oriented synthesis (BIOS) [5], for example, uses biologically validated scaffolds [6][7][8] to inspire library design. Known organic molecules populate chemical space unevenly and unsystematically. Around